SGLT-2 Inhibitors: A New Mechanism for Glycemic Control.
نویسنده
چکیده
Glucosuria, the presence of glucose in the urine, has long been regarded as a consequence of uncontrolled diabetes. However, glucose excretion can be induced by blocking the activity of the renal sodium-glucose cotransporter 2 (SGLT-2). This mechanism corrects hyperglycemia independently of insulin. This article provides an overview of the paradigm shift that triggered the development of the SGLT-2 inhibitor class of agents and summarizes the available evidence from clinical studies to date.
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عنوان ژورنال:
- Clinical diabetes : a publication of the American Diabetes Association
دوره 32 1 شماره
صفحات -
تاریخ انتشار 2014